Testing 4 key antibody biomarkers, including the gold standard tTG-IgA, allows you to know how your body reacts to gluten and whether you have celiac disease.
Antibodies are part of your immune system that identify and help eliminate foreign invaders in your body, like a virus. Autoantibodies—sometimes mistakenly produced by the immune system—attack your own tissues. This can lead to autoimmune disorders, such as celiac disease.
Celiac disease is characterized by inflammation of the small intestines when someone eats gluten, a protein found in wheat and other grains. Autoantibodies mistakenly identify gluten as foreign and attack the small intestine where it is present. The damage can cause abdominal pain, diarrhea, and failure to absorb nutrients from food. Your risk for having celiac disease increases if you have a family history of celiac disease, have an autoimmune disorder, such as thyroid disease or type 1 diabetes, or have some other genetic disorder, such as Down Syndrome or Turner Syndrome.
This test detects the presence of 4 autoantibody biomarkers associated with celiac disease: the tissue transglutaminase (tTG) antibodies tTG IgA and tTG IgG; and the deamidated gliadin peptide (DGP) antibodies DGP IgA and DGP IgG. It can be used to both screen for celiac disease and monitor your disease progression in response to dietary changes.
The results of this test alone will not provide enough information for healthcare professionals to definitively diagnose whether you have celiac disease. Follow-up tests are necessary to identify the cause of any symptoms you are experiencing.
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