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Rheumatoid Arthritis Panel

rheu·​ma·​toid ar·​thri·​tis

Three autoantibody biomarkers are used to test for rheumatoid arthritis, a condition that affects more than 1.5 million Americans¹.

Antibodies are part of your immune system that identify and help eliminate foreign invaders in your body, like a virus. Autoantibodies—sometimes mistakenly produced by the immune system—attack your own tissues. This can lead to autoimmune disorders, such as rheumatoid arthritis. Rheumatoid arthritis is a chronic autoimmune disease that causes inflammation and joint pain, usually starting with small joints in the hands and feet and progressing to other joints.

This test detects the presence of 3 autoantibodies that are common in those with rheumatoid arthritis: citrullinated peptide antibody (CCP IgG) and 2 rheumatoid factor (RF) biomarkers, RF IgM and RF IgA. The CCP antibody test is 97% specific for rheumatoid arthritis². Because low levels of RF autoantibodies have been found in those who do not have rheumatoid arthritis, healthcare professionals might test for other biomarkers and take other health information into account before diagnosing rheumatoid arthritis.


  1. Almutairi KB, Nossent JC, Preen DB, et al. The Prevalence of Rheumatoid Arthritis: A Systematic Review of Population-based Studies. J Rheumatol 2021;48(5):669–676.
  2. Vallbracht I, Rieber J, Oppermann M, et al. Diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis. Ann Rheum Dis 2004;63(9):1079–1084.
Last updated:
September 7, 2021

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