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Lp-PLA2 is a biomarker released by immune cells specifically in blood vessels to cause inflammation. As vascular inflammation is associated with cardiovascular disease, measuring Lp-PLA2 levels is an accurate indicator of the risk of heart disease¹. Elevated blood levels of this biomarker increase your risk of atherosclerosis, chronic ischaemic heart disease, and stroke²,³. Atherosclerosis is a condition characterized by plaque deposits in your arteries, which increases your risk of experiencing blood clots. Half of heart attacks occur in people with normal cholesterol levels, making this an important additional test for cardiovascular health.

Lp-PLA2 can be used along with other biomarkers to assess your risk for cardiovascular disease. To decrease your risk, healthcare professionals may recommend you eat less fatty foods, exercise more frequently, and, possibly, take statins, which lower levels of cholesterol in your body.


  1. De Stefano A, Mannucci L, Tamburi F, et al. Lp-PLA2, a new biomarker of vascular disorders in metabolic diseases. Int J Immunopathol Pharmacol 2019;33:2058738419827154.
  2. Ballantyne CM, Hoogeveen RC, Bang H, et al. Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study. Arch Intern Med 2005;165(21):2479–2484.
  3. Diaconu A, Coculescu BI, Manole G, et al. Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease. J Enzyme Inhib Med Chem 2021;36(1):68–73.
Last updated:
August 16, 2021

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